| Solanesol is a high added value product which has remarkable medical effects such as diminishing inflammation, hemostaria and antibacterial. As addition, it is an important material of medicine monomers and intermediates for the synthesis of vitamin K2 and coenzyne Q10. Solanesol is usually produced from tobacco, in which the content is 0.4%～2.6%. The solanesol from traditional production technology is extracted by organic solvent, which has a number of disadvantages such as high operating temperature, high solvent consumption, environmental pollution. Supercritical CO2 extraction is a highly-effective environmentally benigh separation technology, by which the researches and applications on extracting medical effective components from natural herbs have achieved significative success. In this paper, ethanol is choosed as the entrainer to the solanesol supercritical CO2 extraction experiments by Soxhlet extraction.The optimum conditions of supercritical CO2 extraction are determined by orthogonal experiments: pressure, temperature, entrainer flow rate, CO2 flow rate and operation time are 18 MPa, 54℃, 3 g/min, 10 g/min, and 3 hours, respectively.In the range of the experiments, the effects of each factor to the extraction yield and selectivity are studied by orthogonal experiments: pressure>entrainer flow rate >temperature.It is shown that the extraction yield of supercritical CO2 extraction is higher than it of the traditional production.So the technology supercritical CO2 extraction has a great advantage and a good industrial prospect.In accordance with the results of orthogonal experiments, ANN technology is used to simulate the supercritical CO2 extraction process of extracting solanesol from tobacco. The 3-22-2 EBP model is built up. The training error is 0.0707%, and the testing error is 0.0899%. The reserach provides the theory basis to the designing and optimum of the supercritical CO2 extraction process of extracting solanesol from tobacco.
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