Endocrine Disruption In Zebra Fish Reproduce By Flumorph

In recent years, the effects of endocrine disrupting chemicals on human health and the environment have caused a great deal of concern among scientists and the public. Some pesticides that disrupt the endocrine system are commonly used in domestic situations. Flumorph is a new pesticide, and its effect on the aquatic (zebra fish) endocrine system has not yet been determined. The objective of this study was to evaluate endocrine disruption by flumorph(95 %)in zebra fish, as a guide to safe and effective use of this pesticide. Flumorph was administered to zebra fish at 0.25, 0.5, and 2.5mg/L, with a control group treated with 99.8% E2 at 0.01 mg/L, The study was performed with semi-static system, to investigate endocrine disruption in the reproductive system of parents and offspring. Liver cell swelling was not found in male and female zebra fish treated with flumorph at 0.5 and 2.5 mg/l。Germ cell counts of the E2 group has decreased by around 30% but laying did not decreased with interregnum group .In zebra fish treated with 0.5 and 2.5 mg/L, avoirdupois and germ cell were decreased .Semi-static system of flumorph did induce any changes in avoirdupois but in zebra fish with flumorph at 0.5 and 2.5 mg/l did germ cell decreased, and did not cause changes in the reproductive system or in reproductive ability, indicating a lack of estrogenic effects. Flumorph had no effect on gestation and on parr.