Endocrine Disruption In Rats By Flumorph

In recent years, the effects of endocrine disrupting chemicals on human health and the environment have caused a great deal of concern among scientists and the public. Some pesticides that disrupt the endocrine system are commonly used in domestic situations. Flumorph is a new pesticide, and its effect on the mammalian (SD rats) endocrine system has not yet been determined. The object of this study was to evaluate endocrine disruption by flumorph(97.6 %) in SD rats, as a guide to safe and effective use of this pesticide. Flumorph was administered to rats at 15, 45, and 150 mg/kg/day, with a control group treated with 99.8% DES at 0.01 mg/kg/day, to investigate endocrine disruption in the reproductive system of parents and offspring. Liver cell swelling was found in male and female rats treated with flumorph at 45 and 150 mg/kg/day。Sperm counts of the DES group has decreased by around 50% and sperm morphological abnormalities has increased 1.8 times. In rats treated with 45 and 150 mg/kg/day, sperm counts were decreased and there was a greater incidence of sperm morphological abnormalities. Oral intake of flumorph did not induce any changes in uterine wet weight or size of uterine epithelial cells, and did not cause changes in the reproductive system or in reproductive ability, indicating a lack of estrogenic effects. Flumorph had no effect on gestation and on post-birth lactation.