Research On The Synthesis Of Ionic Liquids And Asymmetric Direct Aldol Reaction In Ionic Liquid

1. Asymmetric Direct Aldol Reaction promoted by (4S)-Phenoxy-(S)-Proline in Ionic Liquid [bmim]PF₆ Room temperature ionic liquid [bmim]PF6 was evaluated for recycling an organocatalyst (4S)-phenoxy-(S)-proline 1 for direct asymmetric aldol reactions. The desired aldol products were obtained with good yields (up to 93.2%) and enantioselectivities (up to 88.5%); isolation of the products by simple extraction allowed recycling of the ionic liquid containing the immobilized catalyst in subsequent reactions without significant decrease of yields and enantioselectivities. 2. Research on the Synthesis of Chiral Ionic Liquids Synthesis and application in asymmetric reactions of chiral ionic liquids have already got preliminary development. A few chiral ionic liquids, which were prepared from (S)-proline and (4R)-hydroxyl-(S)-proline, were designed and synthesized for the Asymmetric Michael and Aldol reactions. Unexpected results were discussed 3. Enantioneric Excess of Asymmetric Reaction Products is Evaluated with HPLC...