Cyclodextrins can be subjected to diverse modifications to give a wide variety of cyclodextrin derivatives, which could not only extend the original molecular binding ability, but also alter the molecular selectivity. Therefore, cyclodextrin chemistry is currently a significant topic in chemistry and biochemistry, which was paid a great deal of attention by chemists. In this thesis 4 modified cyclodextrins were newly synthesized and characterized. And some modern measuring techniques were performed to examine their interactions. The major contents of this thesis are listed as following: (1) The new progress and important achievements in analytical chemistry of cyclodextrins and their derivatives were reviewed. (2) The novel 4 β-cyclodextrin derivatives were synthesized by a convenient method, and identified by using elemental analysis, 1H NMR, IR, UV-vis and fluorescence. (3) The determination of modified cyclodextrins to NO2-1, Cr (VI), ascorbic acid and nucleic acids was studied by using fluorescence and UV-vis. The possible mechanism was also studied. And some sensitive fluorescence methods for the determination of NO2-1, Cr (VI), ascorbic acid and nucleic acids, respectively.
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