Studies On The Technics Of The Racemization And Split Of Dextromisole Hydrochoride

Levamisole hydrochloride, the ramification of imidazole, is a broad-spectrum medicine against wireworm. Compare to its racemate (DL-Tetramisole) , levamisole hydrochloride has more validity and less toxicity. In general, it can be got by disconnecting from DL-Tetramisole . Its dextrorotatory substant is an antidepressant which does not have the helminthic effect.Based on consulting the domestic and international reference documents, two totally different processes are discussed in my paper and a reasonable process is determined by the comparison of process available . In the first one , Our experiment team use ethanol liquor as solvent and achieve the process of racemization of dextrorotatory imidazole in sodium hydroxide environment. And monofactor method and multifactor orthogonalizing design method are applized to get the optimum processing conditions in this racemization process. And then a new split technics, which can not be found in any documentation, is searched after: Through controlling the pH cost and temperature of reaction of the solution, the split process can be easily obtained.Meanwhile, we got the optimum processing conditions. This is exactly one of the innovations in my paper.The following have been obtained through lots of experiments.1. The optimum processing conditions by using ethanol liquor as the solvent in this racemization process:( dextromisole hydrochloride 20g, reaction temperature 70°C, pressure 0.07MPa) racemization time 1.5 hours;volume of ethanol liquor 40 ml;the mass of sodium hydroxide 3.0 grams;proportion of ethanol and water 3:1.2. The optimum processing of the new split technics has been obtained based on a large number experiments, which the optimum processing conditions is: reaction temperature 5°C,pH costs 3.