Effect Of Samarium Nitrate On Learning-Memory Of Mice And The Possible Mechanism Of It

Along with the extensive application of rare earths in many areas, a large quantity of rare earth elements and associated compounds enter the environment. Presently, there were a lot of studies showed that the elements of rare earth might go through the "blood-brain" barrier into the brain and be cumulated in the brain. So, to assess the potential health risks for human, it is essential to investigate the effect of RE for long time on the function of brain, and signality for us to establish the standard of using RE safely and using RE in reason. After the mice(male and female is same in quantity) were given to different dose(5,50, 500,2000 mg/L) of Samarium nitrate (Sm(NO₃)₃) for three months, the mice's learning-memory, acetylcholinesterase, nitric oxide synthase, monoaminergic neurotransmitter,trace elements in brain and the parameter of Gray I synapse interface in hippocampal CA₃ were examined by behavior, biochemistry technology and transmission electronic mic -roscopy. The experimental results showed that:1.After subchronic treatment of Samarium nitrate,(1)the exploring ability of mice in new environment was restrained, the lomotion and the rearing quantity of the female group was lowered remarkably(P<0.05), and the grooming quantity of the male group given to 2000mg/L was obviously...