The Study Of Synthesis Technology Of Cyclohexyl Phenyl Ketone In One Step

Cyclohexyl phenyl ketone(CPK) is an asymmetric ketone. Its molecular formula and molecular structure formula are respectively C13H15O and OCyclohexyl phenyl ketone, as an important intermediate product of medicine and dyestuff, is mainly used for synthesizing cyclohexylphenyl phenyl methanol and ultraviolet photoinitiators such as 1- hydroxyl cyclohexyl phenyl ketone. At present, the industrial process of manufacturing cyclohexyl phenyl ketone is carried out by Friedel-Crafts reaction via cyclohexyl-acyl chloride and benzene. However, this process has obvious shortcoming as the high consumption of aluminium chloride and a mass of poisonous gas, for example, SO2 and HCl. Thus, it is a trend to produce the ketone with a process environment-friendly.This thesis confirmed a one-step synthesis method of cyclohexyl phenyl ketone via benzoic acid(BA) and cyclohexanecarboxylic acid(CCA) by using catalyzed decarboxylation reaction. The set of the reaction was confirmed by using an autoclave reactor. Simultaneously, the analyzing method was established as the following description. The reaction product was dissolved in acetone and the solution was filtrated. The filtrate was analysed to get the mole yield of the CPK and the mole conversion rate of the CCA using high pass liquid chromatogram and gas chromatography respectively.The reaction mechanism of the synthesis of CPK via catalyzed decarboxylation was also discussed in this thesis. According to the mechanism, the real catalysts of the reactions were the transitional metal oxides, which reacted with carboxylic acids and carboxylates were obtained. Then asymmetric ketones were obtained through the thermal decomposition reactions of the carboxylates. It offers academic support to develop the combined process from benzoic acid and cyclohexanecarboxylic acid by using MnO as the catalyst.As MnO was used, the mechanism of the reaction may be: C₆H₅COOH+ MnO+C₆H₁1COOH→C₆H₅COO-Mn-OCOC₆H₁1+H₂O C₆H₅COO- Mn-OCOC₆H₁1→MnO+C₆H₁1CO+C₆H₅+CO₂...