Study On The Preparation Of Lidocaine Microemulsion And Its Percutaneous Penetration In Vitro

Lidocaine is known as Xylocaine, can be used for the various forms of local anesthesia. Lidocaine is anesthetic medicine of the acyl amine , which has mucous membrane penetrability and diffusibility since the effect is strong and the action time lasts long.Every medicine time can maintain 1-2 hours, the safe scope is quite large and stimulative is smaller. The local blood pressure extends not obviously.Currently Lidocaine of the common use in surface anaesthesia is the compound prescribe Lidocaine milk cream, the weakness of this kind of product is slow effect time, and need to inject the Lidocaine soakage anaesthesia at the same time, f anaesthetizing gradually then can attain to better result.Prilocaine, which is among them may bring the positive iron hemoglobin blood disease and contact allergies.In addition, there are Lidocaine gum of gelatin and Lidocaine tincture. The weakness of both is the slow effect time, and permeates skin not ideal enough.Microemulsion is water, oil, surface-activity agents and cosurfactant of an average appearance, and each direction is the same nature, for the transparent or translucent thermodynamics stable dispersion system. This selected works chooses a medicine of microemulsion lotion to carry the body to be used as Lidocaine to carry the body because of the surface anaesthetic, the establishment Lidocaine microemulsion through the skin giving medicine system, which can enlarge the...