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Research On Oxidative Bromination Reaction

Posted on:2007-08-27Degree:MasterType:Thesis
Country:ChinaCandidate:W ChenFull Text:PDF
GTID:2121360185491165Subject:Applied Chemistry
Abstract/Summary:PDF Full Text Request
Oxidative bromination of activated aromatic compounds, such as toluene, naphthalene and anisole, using alkali metal bromide salts and aqueous nitric acid to the corresponding bromo-derivatives is achieved in a liquid-liquid, two-phase system under ambient conditions. Factors influencing the product yield are discussed: such as catalyst type, mol ratio of raw material, catalyst amount, reaction temperature, and reaction time. The better conditions for oxidative bromination are investigated in test. The yield of oxidative bromination has been improved greatly.Nitric acid offers a dual function of an oxidant as well as a proton donor, which is essential for oxidative bromination using metal bromide salts. Phase transfer catalyst extract bromine into the organic phase via the hydrogen-bonded complex, formed in the reaction scheme by anion exchange, which accelerate the generation of product. Tetrabutylammonium bromide (TBAB) was found to be the most effective phase-transfer catalyst in this reaction.
Keywords/Search Tags:Oxidative bromination, Activated aromatic compounds, Phase transfer catalyst, Aqueous nitric acid
PDF Full Text Request
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