The Synthetic Technology Improvement Of The Chiral Zwitterion Of The Carumonam The Synthetic Technology Of 2-methyl-7-piperdineethoxyl-4'-hydroxyl Isoflavone

Postgraduate Candidate Xie Jing Tutor Prof. Weng LinglingProf.Carumonam was first introduced into Japan in 1988. It is the second monobactam after aztreonam. The activity of carumonam against gram-negative bactaeria is similar activity with aztreonam. So far, it has not been produced in China and has good commercial value.Sodium (3S, 4S)-3-amino-4- [(carbamoyloxy) methyl]-2-ox-Oazetidine-1-sulfonate, the chiral zwitterions is the key of the synthesis of carumonam. In our research group, it had been synthesized by 14 steps reactions using calcium L-threonate as a chiral starting material through the method reported by Percy S.Manchand. But there were some shortcomings. In this dissertation, we tried to synthesize it through the method reported by Wei which was used calcium L-threonate or Vitamin C as a starting material (route 1 and 2).