Study On Synthesis Of Isoniacin By Direct Electrooxidation Of 4-picoline

Isoniacin is an important organic fine chemical and medicine intermediate product. It is an important medicament intermediate of isoniazid, which compound to treat tuberculosis. It also mainly applies to anti-cauterization, plating additive, sensitive resin stabilization agents, polyvinyl chloride caloric stabilization agents, colored metal floatation agents, and so on. So it has a abroad applied prospect. The traditional synthesize method of isoniacin always had the defects, such as serious pollution, complex technics, highly cost etc. Direct electrochemical oxidation, which called "green technology", has advantages in fewer invest, lower cost, lighter pollution, finer quality of production etc. So it becomes a hotspot for research in the world. This dissertation studied the analytical method of direct electrooxidation 4-picoline on PbCVTi electrodes in sulfuric acid solution. The electrocatalyse capability of anode and the synthetic technology has also been discussed in this dissertation.The solution of direct elecsynthesis of isoniacin contains isoniacin, 4-picoline and H₂SO₄ , the analysis of all the components has not been reported. In this dissertation, a method of the equivalence absorbency double-wavelength UV spectrophotometry for the determination of isoniacin and 4-picoline has been described. The determination wavelengths were selected at 258nm and 269nm. The relative standard deviation of isoniacin and 4-picoline is 1.35% and 0.83% respectively. The recovery of them is 99.19% and 99.64%, respectively.Based on the properties of the electro-synthesis process of isoniacin, the catalytic activity of PbCVTi DSA and IrO₂/Ti anodes in oxidizing 4-picoline process were investigated by steady-state polarization curve. It was found that the PbO₂/Ti anode exhibited higher overpotential to oxygen evolution, better electrocatalytic activity and can be applied to the electrosysthesis of isoniacin. At the same condition of temperature and the concentration of 4-MP, used PbCVTi as anode, changed the concentration of H₂SO₄, found that the anode has the highest overpotential to oxygen evolution, best electrocatalytic activity when the concentration of H2SO4 is 25%.Isoniacin synthesized from 4-methylpyridine was using direct electrochemical method in...