Dahuang Dispensing Granule Raw Material Screening, Preparation Craft Optimization And Pharmacodynamics Comparison Research

Radix et Rhizome Rhei is the dry root and rhizome of Rheum palmatum L., Rheum tanguticum Maxim, ex Balf. or Rheum officinale Baill., is one of the extensively important traditional Chinese medicine which be used all over the word., also is the commonly used medicine in our country for Chinese medicine clinical. But because the tradition decoction has the disadvantage of big dosage, unstable quality, unconvenient decoction, take and carry, relatively difficult storage and transport, therefore makes it to be Dahuang dispensing granule which is stable and reliable in quality, accurate in dosage, safe and effective, convenient to take, easy to carry, store and transport, this not only makes sure the clinical use convenient, safe, effective, but also expands its use crowd. This topic is a part of "Dahuang dispensing granule Quality specification Standardization Demonstration Studies" which is a 863 project of national science and technology department, mainly through the research of raw material screening, preparation craft optimization, main pharmacodynamics confirmation and security appraise to provide the scientific basis to make sure the end product's stable and controllable, the clinical use security and effective, to lay foundation for the complete of "Dahuang dispensing granule Quality specification Standardization Demonstration Studies" , meanwhile to provide the model for the correlation research.In the raw material screening aspect, this topic did some comparison research to 3 varieties and 6 habitats Chinese rhubarb raw materials in the collection, including origin, character, micro, TLC, heavy metal, arsenic salt, dry weightlessness, ash, extract and content measure. Comprehensive the output and the cost accounting, the raw material of Dahuang dispensing granule was finally determined, which is R. palmatum L. produced in Ganzi state Sichuan province, especially produced in the GAP base.In the preparation craft optimal aspect, This paper mainly studied the technics of eliminating impurity, concentrating, drying, forming of raw rhubarb and the extracting technics of rhubarb processed, the preliminary determination best technology route, and through the experimental trial manufacturing, unified the big production to formulate the Dahuang dispensing granule standardization preparation craft and its the craft technology parameter.The preparation craft and its the craft parameter is: Takes rhubarb 3000g, watering 3 times, the 1st add 9 time of quantities water (add 1 time of quantities water...