The Ring-opening Polymerization Of PDO With PTHF Acts As Macroinitiator

With outstanding biodegradability, bioabsorbability and biocompatibility, and good flexibility due to existence of unique ether bonds, poly (p-dioxanone) (PPDO) is well known as a good candidate for medical use. As a novel material, PPDO has been synthesized in the 1970s, but it has not been widely used now because of its rigorous synthetic condition and some other defects such as low crystallization rate, low melt strength which influenced its processing properties. Therefore , modification of PPDO is necessary to expand its application. Poly(tetrahydrofuran) (PTHF) is biodegradable for the existence of ether bonds in polymer chains. Some polymer materials with PTHF segments have also been used as biomedical materials. It is promising to modify PPDO with PTHF.The copolymers of poly(p-dioxanone)-b-poly(tetrahydrofuran)-b-poly (p-dioxanone) (PPTP) were synthesized by ring-opening polymerization of p-dioxanone in the presence of dihydroxyl poly(tetrahydrofuran)(PTHF) using stannous octoate (SnOct2) as a catalyst in this paper. The copolymers were characterized by various analytical techniques such as 1H-NMR and IR. The effects of feed ratio, reaction time and reaction temperature on the copolymerization were investigated. Their crystallization, thermal stability, mechanic properties , rheology properties and biodegradable properties were investigated by DSC, XRD,...