The Preparation And Performance Research Of Erythromycin-molecularly Imprinted Membrane

Molecular imprinting technology (MIT) which is developing quickly these years is a good method to create functionality macromolecule material for effective recognition specifical substance through "memory effect" of molecular imprinted polymers (MIPs). More and more people focus on the application in chromatography, chiral compound separation, molecular recognition sensor, microanalysis and so on.Molecularly imprinted membranes (MIMs) which are combined with molecular imprinting technology and membrane separation technology have characteristic of them. Compared with ordinary separation membrane, MIMs have high selectivity for specifical substance. Compared with traditional molecular imprinted polymer, MIMs' preparing process doesn't need smash and have high imprint bind cavity hold rate. MIMs get breakthrough ordinary membrane separation technology and will be hotspot of functionality membrane.In this study, we use erythromycin(EM) which is one of antibioticas as template molecule, acrilonitrile(AN) as membrane formation segment, ethacrylic acid(MAA) which have -COOH group as function monomer, through non-covalence imprinted technology to prepare imprinted membrane by phase inversion imprinting method, and then wash off template molecule in ethanol with ultrasonic instrument. In the experiment, the influence factors for MIMs separation efficiency, such as material ratios, dosage of template molecular and solvent, reaction time and reaction temperature are discussed in detail. The structure and characteristic of MIMs was studied and get important result by SEM, AFM, FT-IR, XRD, DSC.Experiment result indicated, erythromycin imprinted membrane has an asymmetric porous structure, and there are lots of imprinted bind cavity on the rough surface. Quantity of interaction imprinted bind of template and function segment in the MIMs is 1.0736×10^-3mmol/cm³. MIMs belong to sub-crystal polymer. Theory retention molecular weight is 1178, erythromycin retention and water flux are 53% and 64L·h^-1·m² respectively. Compared selectivity of EM imprinted membrane with non-imprinted membranes, permeation experiments showed that EM imprinted membrane had high EM separation ability. This work has important meaning for development and perfect of MIMs.