L-Prolinamide Catalyzed Direct Aldol Reactions In Pure Water

In these thesis, L-prolinamide catalyzed direct aldol reactions in pure water were studied in detail. The results indicated that L-prolinamide can effectively catalyze aldol reaction of ketones with a variety of aldehydes, good to excellent yields and diasteroselectivity were obtained in pure water. The L-prolinamide catalyst can be recycled and reused very efficiently for many tines.Comparing with proline, L-prolinamide catalysis aldol reaction exhibits the follow advantages: broader substrate generality, greater catalytic reactivity, higher yields and diasteroslectivity, This is an environmentally friendly system for preparation syn-β-hydroxyl cyclopentanones.