Experiment Research Of Producing Theunformed Cefuroxime Axetil By Means Of Supercritical Supercritical Antisovent Crystallization

Cefuroxime axetil belongs to cephalosporim antibiotic. Here are three polym-orphs which areα,βand the unformed for cefuroxime axetil but onlyβand the unformed are able for us, however, the unformed cefuroxime axetil is permitted to produce exclusively. The paper introduces the way to get Cefuroxime axetil power and the unformed cefuroxime axetil by means of supercritical antisovent crystallization.The paper introduces that we use a continuous gas supercritical antisovent instrument to get cefuroxime axetil power by supercritical antisovent process. Our research object is the object system of cefuroxime axetil- acetone- carbon dioxide. The paper uses three ways of SEM, X-ray diffraction and Infrared spectrum to check the unformed cefuroxime axetil by GAS ; and we also check the reliability of the instrument. At the same time, we do much research about the influence of the crystal size in different testing conditions (temperature, crystallization pressure, the value of gas and fluid flow rate, cefuroxime axetil concentration and nozzles).The result is that temperature, crystallization pressure, cefuroxime axetil concentration and the value of gas and fluid flow rate are the most important in all these test conditions. We also check the separate impact of these three test conditions (crystallization pressure rises, the crystal average size reduces; concentrations rise, the crystal average size increases; the value of gas and fluid flow rate rises, the crystal average size reduces).We also analysis the possible reasons. The unformed cefuroxime axetil which has smaller crystal average size is produced successfully.