| In this paper, we have reported synthesis and characterization of the flavonoids and flavonoids Schiff-bases complexes, and studied their biological activities. One kind of flavonoids and two kinds of flavonoids Schiff-bases and their complexes have been synthesized.In the first chapter, we summarize progress in DNA, pharmacological research of flavonoids and interactions of metal complexes with DNA.In the second chapter, the naringenin ligand and its three transition metal complexes, M(H2L1)2·4H2O (M (II) = Cu,Zn and Ni), have been synthesized and characterized on the basis of elemental analyses, molar conductivities, IR spectra, 1H NMR spectra and thermal analyses. In addition, the suppression ratio for O2-· (a) and the suppression ratio for OH·(b) were determined with 721 spectrophotometer.In the third chapter, the naringenin ligand and its four rare earth complexes, La(H2L1)2(NO3)·4.5H2O, Eu(H2L1)2(NO3)·2.5H2O, Ln(H2L1)2(NO3)·nH2O (Ln(III) = Dy, Sm, n = 3), have been synthesized and characterized on the basis of elemental analyses, molar conductivities, IR spectra, 1H NMR spectra and thermal analyses. In addition, the suppression ratio for O2-· (a) and the suppression ratio for OH·(b) were determined with 721 spectrophotometer.In the fourth chapter, the naringenin Schiff-base ligand and its four rare earth complexes, Ln(H2L2)2(NO3)·2H2O (Ln(III) = La, Sm, Dy and Eu), have been synthesized and characterized on the basis of elemental analyses, molar conductivities, IR spectra, 1H NMR spectra and thermal analyses. In addition, the suppression ratio for O2-· (a) and the suppression ratio for OH·(b) were determined with 721 spectrophotometer.In the fifth chapter, the chromone Schiff-base ligand (L3) and CuL3·OAc·H2O complexes have been synthesized and characterized on the basis of elemental analyses, molar conductivities, IR spectra, and 1H NMR spectra. In the sixth chapter, we investigate the interactions of flavonoids Schiff-base ligand and complex with calf thymus DNA. The results show apparent absorption hypochromism, dramatic fluorescence enhancement and substantial viscosity increase in the presence of ctDNA, indicating that complex and ligand bind to DNA both by intercalation modes, but the binding affinities of the complex to DNA are much higher than that of ligand.
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