Design And Synthesis Of 4'-Thioadenosine

The virulent disease is one of the most harmful dieseases in the world, nowadays, more and more people afflicted virulent disease, so we need new and effective antivirus medicines. In recent years nucleosides have been close attention to medicinal and organic chemists due to their antiviral and antitumor activity. Untill 2002, the medicine which used in clinically is more than 19. For examples, Lamivudine, Acyclovir as successful antiviral drugs, have been used to the vast number of patients. Moreover, in the whole world the number of people who affect AIDS have increased, the HBV unceasingly spreads, the new virus unceasingly produces, like SARS cause international panic. Untill now, we can not cure new bird flu. However, due to the cost, cytotoxicity, side effects of the commercially available drugs forced to developed new templets.Nucleosides common character is every compound all formed by sugar and base, in the matter of chemical constitution, nucleosides and natural nucleosides have very similar character. So we can from two parts to change necleosides, (1) from sugar, (2) from base. Because sugar part is very important for antivirus activities, so changing sugar part can increase antivirus activities, as the same time, it can also decrease side effects. So we decided to design and synthesis 4′-thioadenosine from sugar changing. In view of this, my thesis is consists of design and synthesis of 4′-thioadenosine which is the thio analogue of classical oxa nucleosides.