The Preparation Of Molecularly Imprinted Monolithic Columns And Applications In The Separation And Analysis Of The Medicine

The molecularly imprinted monolithic columns, which combine the high stereoselectivity of molecularly imprinted polymers with the advantages of good hydrodynamic characteristic, low flow resistance as well as easy preparation of monolithic materials, have potential applications in the separation and analysis of the medicine. This includes the synthesis of cross-linked polymers in the presence of templates. Removal of the template from the formed polymer thus generates a structure complementary to the template structure or to an analogous structure. With the characteristics of the monolithic columns, this paper is covering some aspects of the synthesis and applications of imprinted materials, and divided into four chapters.The first chapter discussed the historical perspective and fundamental aspects on the synthesis, recognition and application by imprinted polymers. The second chapter studied the monolichic molecular imprinted polymer(MIP) of triadimenol which was prepared by using methylacrylic as functional monomers. The MIP had special recognition performance and seperation of triadimenol and its analogues, which was used to be the stationary phase of the high performance liquid chromatography.The third chapter studied the analytical applications of the MIP given, and investigated the adsorption isotherm of the imprinted polymers. Repanlinide and its enantiomers were seperated in the MIP column, which was used to be the stationary phase of the high performance liquid chromatography. In the last chapter, the monolithic columns were applied to the extraction of the glycyrrhizic acid.