Core-shell Type Multiarm Star Polymers: Synthesis And Guest Encapsulation Potential

Compared with traditional liner polymers, hyperbranced polymers have many peculiar properties. For nowadays, it has attracted much of interest for the applications of hyperbranced polymers in medical materials, non-liner optical materials, solid hydronium surfactant, supramolrcular chemistry and nano-materials. Especially, since the micelle nature of amphiphilic star multi-arm polymers, it has large potential to be used in gene therapy, drug delivery and preparation of nano-structure materials.Because the polymer micelle is self-assembled by the amphiphilic star multi-arm polymers, its structure is unstable. However the synthesize of dendritic moleculars is complex, time-consuming and with high cost of raw materials. In this essay, the HPEI10K andε-caprolactone (CL) are used as the main materials via ring-open polymerization to get amphiphilic star multi-arm polymers, from which molecular micelle is made. It is easy to operate and to get raw materials.The research of this essay is mainly focused on the influence of the reaction temperature and ratio of raw materials on the synthesize and productions, the modification of end groups of the productions, as well as comparison of different anionic dyes phase transfer that ensure the capacity of encapsulation of the productions. In the experiment, it was concluded that the result of polymerization achieved the best under the temperature of 130℃. As for HPEI10K, when the ratio of CL to amidogen is 40:1, the productivity is at the highest level.In the experiment of phase transfer, the conclusion is drawn that the capacity of encapsulation of polymers is definitely increased after the modification. However, with the consideration of the huge loss of the experiment, in the industrial application it is much economical to choose the star polymers directly composed; yet in the medical application, the modified star polymers should be used.