Selective Extraction And Molecular Recognition Of Cyclodextrin And Its Derivates To Pharmacy Compounds

Cyclodextrins are widely used in the field of molecular recognition.It could form inclusion compounds with organic compounds,inorganic compounds and biology compounds because of supermolecular interaction.Recently,β-cyclodextrin derivatives such as 2-O-(2-hydroxyethyl-β-cyclodextrin)and 2-O-(2-hydroxylpropyl -β-cyclodextrin)and methyl-β-cyclodextrin which have good solubility are widely used in drug complex for drug carrier and recognition,increasing drug solubility and bioavibility.My work focus on the recognition and selective extraction of cyclodextrin and its derivatives 2-O-(2-hydroxypropyl)-β-cyclodextrin(2-HP-β-CD), 6-O-(2-hydroxypropyl)-β-cyclodextrin(6-HP-β-CD),6-polylacticacid-β-cyclodextrin (6-PL-β-CD).This work has two parts.One is the recognition process and enhanced solubility to guest detected by UV-Vis spectroscopy and the other is the selective separation of 2-HP-β-CD to the flavones of papaya leaves and small molecules.The content of the paper was showed as follows:1.The inclusion constant ofβ-CD derivates to pharmacy with low solubility (rutin,amoxicillin)for molecule recognition have been calculated.Comparing the different molecules recognition ability,it was found that theβ-CD derivates showed strong recognition ability which could be used as good efficient enhanced regent for rutin and amoxicillin.Naphthylacetic acid(NAA)and 6-benzyl aminopurine(6-BA) have been used in many areas as good artificial plant growth regulators.But the time for storing is short.The vitality could be found if we can find a good storage agent. This paper focuses on the inclusion behaviors ofβ-CD derivates to NAA and 6-BA.It would provide some useful information on controlling and releasing NAA and 6-BA.2.The inclusion constant ofβ-CD to low solubility pharmacy(such as rutin, amoxicillin,NAA,6-BA)has been studied by phase-solubility method,which has provided a valuable reference for enhanced solubility and controlled drug release.3.The trials for extracting the flavone from the papaya leaves have been directed. The influences of solvent,temperature,and concentration of the host-guest molar ratio were discussed.The best condition was as follows:2-HP-β-CD(lmmol/l),raw materials 1:20,60℃for 3h.4.The 2-HP-β-CD was used as extract agent,the separation of benzene-toluene system,benzene-phenol-benzaldehyde system,benzene-aniline-phenol-benzylamine system and benzene-phenol-benzoic acid system have been directed.Different recognition ability of 2-HP-β-CD to small organic molecule was discussed.