Synthesis And Application Of The Derivate Of β-cyclodextrin With Oligomeric Easters

β-Cyclodextrin(β-CD) can selectively include with many organic moleculars, inorganic moleculars and biomolecules to form host-guest and supramolecule complexes,which is usually applied in its recognition to many moleculars. However,the solubility ofβ-CD in water or organic solvents is poor and lacks some necessary functions.Therefore,in order to obtain water-soluable derivates ofβ-CD,modifying the structure ofβ-CD is now the hot spot of research in the field.Hydroxpropyl cyclodextrins(HP-β-CD),one of the derivatives ofβ-CD,which can be easily and massively systhesized and possess a fine recognition ability,has been put into practice in a large scale at present.α-Glycolic acid is degradable and clean resource,of which glycolide is its respective dimers.Polyα-glycolic acid is glycolide's autopolymers.Polyα-glycolic acid is degradable and non-polluting materials.They have not only good physical properties but also good biocompatibility and degradation property.Research to them has been done more than others.Their application in medicine carrier and controlled release matearial is much concerned at present. If glycolide can be combined withβ-CD,a novel valuable medical material——a derivative ofβ-CD with favorable properties will probably be obtained.With the results we synthsized and studied copolymer of glycolide andβ-CD.Introduced into degradable group of oligomer ofα-glycolic,function ofβ-CD has been changed and degradable group brings about new properties.The influence of degradable group's kinetically degradability toβ-CD enable the controlled release of Amoxicillin.Besides,The inclusion ofβ-CD and HP-β-CD to the guest moleculars such as phenol and the inclusion constant was both studied.This graduation thesis can be divided into three parts:1.Synthesis ofβ-CD withα-glycolic acid oligomerization,andα-glycolic acid oligomerization.Among the cyclodextrin derivatives,ester derivatives play an important role.Through ring-opening reaction of glycolide,we successfully make glycolide grafted toβ-CD and firstly sythesisedβ-CD withα-glycolic acid oligomerization,α-glycolic acid oligomerization,which is characterized.We also tried to sythesis them under solvent-free condition and obtionedα-glycolic acid oligomerization.2.Inclusion and controlled release of AmoxicillinBased on the degrade of graftedα-glycolic acid oligomerization,dynamic degradation was used to combine the method of traditional drug release ofβ-CD and polyester to firstly realize the release the drug of Amoxicillin byα-glycolic acid oligomerization.What's more,FT-IR and DSC of inclusion ofβ-CD withα-glycolic acid oligomerization/Amoxicillin was firstly studied.3.Recognition of several kinds of moleculars such as phenol byβ-CD and itsits derivatesThrough the method of equivalent molarity(Job's method),the inclusion ofβ-CD withα-glycolic acid oligomerization to the guest moleculars such as phenol and the inclusion constant was both studied.Otherwise,we also studied the inclusion ability ofβ-CD and hydroxypropylβ-CD to several kinds of moleculars such as phenol.In this paper,there are several investigation:1.β-CD withα-glycolic acid oligomerization was firstly synthesised.2.Controlled release of Amoxicillin byα-glycolic acid oligomerization,was firstly studied.3.FT-IR and DSC of inclusion ofβ-CD withα-glycolic acid oligomerization/Amoxicillin was firstly studied.4.The inclusion ofβ-CD withα-glycolic acid oligomerization to the guest moleculars such as phenol and the inclusion constant was both studied.And the inclusion constant of several guest moleculars such as phenol was also caculated.