Total Synthesis Of Twelve Members Cyclic Tripeptide

As an important kind of peptide compounds, cyclopeptide has an encouraging prospect for development in the field of biological medicine and pharmacy. Compared with linear peptides, the degradative capabilities and anti-enzymatic hydrolysis ability of biological cyclopeptide is better. Biological cyclopeptideis also endowed with promising future in finding enzyme inhibitor, receptor antagonist and many other respects. With the steady development of the study of the cyclopeptide combination base, it may become a very good diagnostic and remedial tools in the work of looking for receptor and pharmacological target. The thesis aims to make a study on total synthesis of twelve member cyclictripeptide. Three protectedβ-amino acids were synthesized separately and they were connected in the form of peptide bond to generate linear peptide as precursor of cyclization. The cyclization reation of linear peptide is undergoing.