Preparation Of Coaxial Electrospun-Nanofiber Delevery System Applicable To Traditional Chinese Medicine

The composite fibers with poly(lactic-co-glycolic acid)(PLGA) as shell were biocompatible and biodegradable,and the degrade rate could be adjusted by adopting different molecular weights and composition of PLGA,which has been widely used as carriers to realize controlled drug delivery in forms of microparticles or microcapsules.In this paper,the release behaviors of two types of model drugs(5-fluorouracil and nifedipine) encapsulated in coaxial eletrospun fibers with PLGA as shell and poly(vinyl pyrrolidone)(PVP) as core were studied,respectively.The morphology and core-shell structure of fibers were characterized by scanning electron microscope(SEM) and transmission electron microscope(TEM).The cumulative releases of drug-loaded fibers were examined by ultraviolet spectrophotometry.The experimental results indicated that composite fibers with core-shell structure and different sizes of diameters could be attained by adjusting LA/GA composition,molecular weights of PLGA,concentration of the inner and the outer solution.Meanwhile,the molecular weight and composition of PLGA have a great effect on drug release from fibrous membranes.The release profiles of 5-FU exhibited a great burst release with the degradation of PLGA, while that of NIF displayed a steady in vitro release.Different types of drugs loaded in composite fibers resulted in different release profiles,although they were prepared under the same process.Meanwhile,chinese medicine, annonaceous acetogenins-loaded fibers with PLGA as shell have the similar release behavior with NIF.So coaxial electrospun fibers with PLGA as shell could meet the desired release time of different drugs,which would be applied in drug delivery system in the future.