Study On Environmentally Friendly Reaction Of Carbonyl Compounds With Alkyl Halides By Metals

In recent years, society sustainable development and relating problems on ecology, environment, resources, economy and so on have ever increasing been a hot topic in the international society and have been elevated to a height of development strategy. So green chemistry have arrived at rapid development, environmentally friendly-economics have become an important impetus of technology innovator, and it was serious challenge of traditional organic synthesis, and make green organic synthesis gained a good development chance. Developmed more benign synthetic procedures in chemical synthesis is important in moving towards sustainable technologies. Many new methds of green synthesis were created and investigated by chemists from all country, for example, the organic solvent were repaced by H2O, supercritical CO2, polyethylene and polypropylene glycol, room temperature ionic liquids. An alterative approach aviodsthe use of a reaction mediumas the so-called'solvent-free'or'solventless'reaction. These methods reduced the amount of waste, and environmental pollution, more importantly, it was can be provide new molecule surroundings, and may be improve the selectivity, transform efficiency, and operation efficiency. Therefore, solvnt-free organic synthesize technology under environmentally friendly now has become the hotspot in the organic synthesize studying, it was also an impotant part in the green chemistry.Metal-promoted reaction is provided with extraordinary worthiness of research as a reaction system. In recent years, the applications of Metal-promoted reaction in organic synthesis have become a new research focus. The reactions of have several advantages such as the quick speed of reaction, higher of chemical selectivity, region selectivity and solid selectivity, so it is a kind of synthesis reagents with considerable applicable value and applicable prospect.The thesis mainly invetigated the the reaction that zinc powder or zinc coper couple mediated allylation, bisalylation, and esteration of carbonyl compounds with aryl or alkyl halides, and we were also researched proposed mechanism for these reaction. This thesis includes four chapters. Chapter one: The investigation development of metal zinc mediated organic synthesis reaction.This chapter summerized the relevant research progress of reaction under H2O, supercritical CO2, ionic liquids and solvent free conditions. Moreover, it was summerized that the appliation of metals in organic reaction, and gained the recent progress and result.Chapter two: Study on the allyation of carbonyl compounds mediated by zinc copper couple.This chapter mainly investigated the reaction of aldehydes and allyl bromide to synthesis of homoallylic alcohol mediated by zinc copper couple under solvent free conditions. With optimizing the reaction conditions, twenty-one compounds of homoallylic alcohol were gained. This reaction procedure simply operating, shorter reaction time, good yields and broader applylation scope. Our reaction conditions was environmental friendly reaction procedures, and provide a convenient, efficient synthesize methods of homoallylic alcohols.Chapter three: Study on the gem-bisallylation of carbonyl compounds mediated by zinc copper couple or zinc powder.In this section, we studied gem-bisallylation of carboxylic acid derivatives with allyl bromide mediated by zinc copper couple or zinc powder under solvent free conditions. Synthesising of fourteen compounds of gem-bisallylation alcohols. It was found that these reaction simply operating, shorter reaction time, good yields and environmental friendly.Chapter Four : Study on the esteration reaction of carbonyl compounds mdiated by zinc.This chapter mainly investigated aldehydes, acetic anhydride and phenacyl bromide three components one pot synthesis of acetate esters under solvent free conditions, and gained twenty-four compounds. Twenty-two compounds are novel products. All products were characterized by melting point, IR, 1H NMR, 13C NMR, MS and elemental analyses, and we also investigated mechanism for these reaction.