Synthesis, Characterization, And Catalytic Properties Of The Managnaese Catalase Model Compounds And Their Applications

Many catalytic mechanisms, structural information of manganese enzymes were obtained with the assistances of their model compounds owing to the studies of model compounds are much easier than that of the enzymes, therefore model compounds study is one of the important method for enzymes research. In addition, the enzyme-like activities of the model compounds exhibit potential applications in many fields.Three carboxylate bridge-containing dinuclear manganese models were synthesized, [MnⅡ2(bpmapa)2(H2O)2](ClO4)2 (1), [MnⅡ2(pbpmapa)2(H2O)2](ClO4)2 (2), and [MnⅡ2(bpmaa)2(H2O)3](ClO4)2 (3)(bpmaa= bis(2-pyridyl methyl)amino)acetic acid); pbpmapa=α-phenyl-β-[bis(2-pyridylmethyl)amino]propionic acid and bpmapa= bis(2-pyridylmethyl)amino)propionic acid). The structures of the three compounds were characterized with X-ray diffraction, UV-vis spectroscopy, element analysis, and electron paramagnetic resonance spectroscopy. The catalytic activities of three compounds were systematically investigated. We found that the differences in their activities were contributed by their different bridging modes of the carboxylate group.Based on the catalase-like catalytic activity of complex 1, we explored the application of complex 1 in determination of urinary oxalate concentration. A facile method of the urinary oxalate determination was developed. The method is inexpensive, simple and sensitive comparing with the other existed methods.In addition, we explored the catalytic activity of the complex 1 in phenols decomposition.2, 6-dimethoxyphenol was chosen as an example substrate. The pH reaction time, and reactive molar ratio of the catalytic reaction were investigated. Preliminary results showed that the compounds we synthesized are likely efficient catalysts in phenol compounds decomposition.