One-pot And Green Synthesis Of Isoxazol-5-one And Pyrazol-5-one Derivatives

In recent years, organic heterocyclic compounds have been developed rapidly in the field of organic chemistry, and take an important signification not only in theory but also in practical application aspects. The heterocyclic compounds containing nitrogen such as isoxazole, pyrazole, thiazole are some important compounds of biological ac tivity and play an extensive application in modern medicine and pesticide aspects, is a focus of the research of drug nowadays. Chalcone and its derivatives are important organic intermediates, and widely used in coordination chemistry and super-molecular chemistry. As a kind of versatile intermediates, chalcones have been used widely in the synthesis of organic compounds and medicines.There are mostly biological activities, such as antibacterial, antiphlogistic, acesodyne, anticonvulsant, anticancer, bactericide, herbicide, pesticide and plant growth regulator and so on, so many drug chemists and pesticide learners pay attention to these heterocyclic compounds. In view of new synthetic method, the novel derivatives of isoxazole-5-one, pyrazole-5-one were synthesized by one-pot synthetic method and green procedure.The thesis includes two major parts:The first part is about literature review. The important biological activity, synthetic methods and chemical characteristics of the isoxazole, pyrazole and thiazole derivatives that have been studied in china and other countries were explicated briefly.The second part is about experimental content. Major work as follows:1. One-pot synthesis of 4-arylmethylidene-4,5-dihydro-3-phenyl isoxazol-5-ones2. One-pot synthesis of 4-arylmethylidene-4,5-dihydro-1,3-diphenyl pyrazol-5-ones3. One-pot synthesis of novel 4-arylmethylidene-4,5-dihydro- 3-isopropylisoxazol– 5-ones and 4-arylmethylidene-4,5-dihydro-1-phenyl-3-Isopropylpyrazol-5-ones4. Synthesis of N-(4-1,3-diphenyl-5-chlor -pyrazol-5)-N'-( phenyl-thiazole-2-) N-(1,3-diphenyl-5-chloro-pyrazole-4-yl)-N'-(arylthiazol-2-yl)-formylhydrazone and N-(4-arylthiazol-2-yl) -benzyloxy acetophenone hydrazone...