The Synthese Of Oxazolidine Involved Furan Diheterocyclic Compounds Via One Reaction

Diheterocyclic compounds represent an important class of multiple heterocycles that can be broadly found in many natural products and pharmaceutically important substances. Therefore, a tremendous number of synthetic methods to approach diheterocyclic compounds is known. Most syntheses can be generally divided into three categories: the first, most frequently used method, is the cross-coupling of two heterocyclic and the second, construction one of the heterocyclic cores by cyclization then another and the last rarity one is form the two heterocycles at almost the same time by domino reaction.Oxazolines appear in numerous medicinally active compounds and natural products of biological significance.Additionally, they are valuable as synthetic intermediates or protecting groups in organic synthesis and commonly appear in ligands for asymmetric synthesis.Cyclopropanes are extremely versatile building blocks in organic synthesis owing to their ready accessibility and good reactivity. Since the first report by Cloke in 1929 that cyclopropyl ketones can be transformed into dihydrofuran derivatives, the synthetic applications of cyclopropyl ketones have been well studied.This paper describes the basis of preliminary work, including the work of Yanzihong and the chemical communication of Zhangzhiguo. Herein, we wish to report the CuX2-mediated novel route of furan involved diheterocyclic compounds synthese via domino cyclization reaction of compounds to afford quaternary ammonium salts , which was involved unexpectedly linear gegen ion.