Microwave Aassisted Synthesis Of Imidazo[2, 1-b] Thiazoles Derivatives And The Research Of Decomposition Of EDA

Microwave irradiation technique has been applicated in organic synthesis since the 20th century eighties. Compared with the classical heating, the microwave technique have many advantages which can make the reaction system heating uniformly, increase the probability of collisions between molecules, reduce the reaction time, and improve the product yield and so on.Imidazo[2,1-b]thiazoles has been used as anthelmintic, antihypertensive, immune system inhibitors, bacteriostatic, herbicide, antitumor, and cardiotonic activity. Imidazo[2,1-b]thiazoles is a class of bioactive substances.This paper syntheses a series of imidazo[2,1-b]thiazoles by microwave irradiation technique. The specific conclusions are listed as followed:1. In the power of 200W, we have synthesized a series of 6-Arylimidazo [2,1-b]thiazoles firstly by microwave irradiation technique, and received higher yield in a short time.2. We have studied the Heck reaction on the 6-Arylimidazo[2,1-b]thiazoles by catalysis of Palladium(0), and obtain a series of 5-Substituted-6-Arylimidazo[2,1-b] thiazoles. In the power of 400W, the Heck reaction has high regioselectivity, and the substrates can bear substitutent in the fourth position in the imidazole ring. And the withdrawing electronic halogenated alkylbenzene can react more easily than other halogenated alkylbenzenes.Occurring and synthetic cyclopropanes bearing simple or complex functionalities are endowed with a large spectrum of biological properties, including enzyme inhibition and insecticidal, antifungal, herbicidal, antibiotic, antitumour, and antiviral activities and so on. In chapter 4, we have studied the reaction between EDA and styrene, in the Chiral catalyst system SalenRu(â…¡) and CO. And the EDA's self-polymerization has also been studied. We can see the distribution ratio of different products.