The Synthesis And Reactions Of Epoxychalcone With Phenylhydrazine And Urea

Epoxychalcones are very important synthetic intermediates and can serve as versatileprecursors in synthesis of many natural products, pesticide and drug molecules.Based on the previous work of our laboratory, some new approaches to the synthesis ofthe heterocyclic compounds were explored to extend research field. In this paper, we presentesome results as follows: Under ultrasound irradiation, the synthesis of epoxychalcone via theone-pot way reactions of acetophenones and arylaldehydes oxidated by aqueous hydrogenperoxide in ethanol, the synthesis of 5-aryl-1,3-diphenylpyrazole via the reactions ofepoxychalcone and phenylhydrazine catalyzed by HCl and the synthesis of 5-phenyl-5-arylmethylhydantoin (or 5-phenyl-5-arylmethy-2-thiol hydantoin) via the reactions ofepoxylchalcone with urea(or thiourea) catalyzed by KOH in ethanol at 50 oC. Epoxylchalconeand phenylhydrazine reacted to synthesize 1,3-diphenyl-5-arylpyrazoles at 230 oC undersolvent-free condition also give a favorable result.