Syntheses And Ion Binding Properties Of Molecular Reactors

Molecular recognition is an important branch of supramolecular chemistry, and is also a common phenomenon in biological system. For example, the formation of the substrate-enzyme complex is the key step for the excellent selectivity and efficiency of the biocatalysis. For its broad application prospects in ion-selective separation, catalytic reactions,drug release and so on,various functionalized molecular reactor were synthesized to increase their solubility and to enhance the selectivity and efficiency of their complexation properties. As the anion play a central role in biology, medicine and the environment, design and synthesis of different anion-selective artificial receptors has attracted considerable attention of late. To the best knowledge of us, amide,Urea and thioureagrops were introduced into various receptors and behaved fine affinity to anions.In this context, two novel C3v symmetrical host molecules were obtained by directional synthesis and the self-assembly method and further research on the ion binding properties was carried on.(1) A functionalized N4-calix[6]arene with C3v-symmetry was synthesized from tris(6-tosylmethyl-2-pyridylmethyl)amine and trismethy lated calix[6]arene, the characterization by ESI-MS, 1H, and 13C NMR spectra was carried on. The anoin coordination properties of the synthesized compund were investigated by UV spectroscopic titrations and ESI-MS in CH3CN/CHCl3(9:1V/V). it is clear that the anion affinity of receptor L1 is NO3- >Br->CH3COO->Cl->F-.(2) A novel C3v symmetrical host molecular L2 was prepared fromα-cyclodextrin and pyridin-2-thiol and characterized by ESI-MS and NMR. As an outlook, considerations continue to animate efforts to produce artificial receptor systems that can mimic biological anion recognition and transport phenomena.