Zinc-mediated Electrochemical Allylation Of Aldehydes In Aqueous Ammonia

Synthesis of homoallylic alcohols applied widely in organic synthesis by allylation of carbonyl compounds is one of the most important processes in organic synthesis due to their versatile use as important building blocks for natural product synthesis. The introduction of allylic groups into carbonyl compounds has been achieved by using allylic organometallics in organic solvent. Organic reactions in water have been widely studied in order to minimize the use of organic solvent, many of which are flammable, toxic, or carcinogenic. This paper contains two parts:The overview of recent synthesizing homoallylic alcohols by allylation of aldehydes is shown, especially mental mediated allylation of aldehydes including indium, zinc, tin, magnesium, bismuth, gallium, manganese and antimony.Electrochemistry is interested with more and more attention due to its non-toxicity, non-population, wild condition and low cost. The development of electrorganic chemistry and recent investigations on allylation of aldehydes and ketones are stated in this paper. The project focuses on the behaviors of aldehydes. Allylation of aldehydes were completed successfully in this electrochemical method. Both the aromatic and aliphatic aldehydes can be utilized in this methodology, and mechanism of this reaction was investigated by many methods such as X-ray diffraction, scanning electron microscope, cyclic voltammetry. This is the first report on allylation of aldehydes in alkaline solution.