Studies On The Synthesis And Application Of Tripodal Compounds

Tripodal ligands are a series of compounds which are based on carbon-atom, nitrogen-atom, boron, phosphorus or cyclic structure. The attachment of three flexible donor-atom-containing chains to a framework leads to tripodal ligands, which can form stable complex with many cations, for example, alkali metal ions, alkaline earth metal ions, transition metal ions. Studies on the synthesis and properties of new tripodal compounds are of great value for simulating bioprocess and researching the application in biomedicine fields. In this paper, we synthesized a series of new tripodal compounds and their transition mental ion complexes. All of tripodals and their complexes were characterized by IR, UV, 1HNMR, 13CNMR, etc. The antitumor activities of the tripodal compounds were also studied.1. Four compounds were synthesized from trimethylolpropane, chloroacetic chloride, morpholine, piperidine, and piperazine etc, through acylation reaction and alkylation reaction etc. Their structures were characterized by IR, 1HNMR, 13CNMR. The affecting factors of acylation reaction were studied. The results show that the optimal reaction conditions of acylation reaction are as follows: chloroform as the solvent, triethylamine as the acid binding agent, the molar ratio of trimethylolpropane to chloroacetic chloride and triethylamine 1:3.3:3.3, 24 h, .Under above conditions, the yield of product was 80%.2. The coordination ability of 2b and 2d with transition metal ions ( Cu²⁺, Mn²⁺, Zn²⁺, Fe³⁺) was considered. The results show that the coordination ability with transition metal ions of 2b and 2d was Cu²⁺> Mn²⁺> ( Zn²⁺, Fe³⁺), Cu²⁺> Mn²⁺> Zn²⁺> Fe³⁺, respectively.3. The anti-tumor activities of tripodal and its complexes were determined. The study results show that the tripodal and its complexes have anti-tumor activities. The inhibition human lung cancer cell active of 2d is lower than complexes of 2d with copper and iron, but higher than complexes of manganese. These results will provide some useful information for the syntheses of powerful anti-tumor drugs.