The Synthesis And Drug Controlled Release Of Amphiphilic Isotactic Comb-like Copolymers

Amphiphilic and comb-like copolymer is a kind of polymer material which has special chain and is very useful. At present,it has become a hot topic in the field of polymer reseach. The researchers successful synthesis a series of amphiphilic comb copolymer by anionic/ cationic polymerization and radical polymerization methods, they promote appliances where are all kinds of fields.But the synthesis of high isotactic amphiphilic and comb-like copolymer is rarely mentioned. With P(St-co-CMS) and DMAEMA as raw material,we has synthesis to P(St-g-DMAEMA),and it was investigated self-assembly process in selective solvents by DLS.And the morphologies,which was sphere,of the micelles was verified by TEM images. The micelle still exhibited efficiently properties as drug carrier in deionized water from the drug controlled release study.1) By adding organometallic barium salt in anionic polymerization system, a double metallic system was built.The synthetic conditions about manufacturing stereoregular PS were also investigated.The result is shown that the isotacticity of this product is about 31%. The products were characterized by FT IR,DSC,XRD and 13C-NMR,and their structures and molecular weight had been confirmed.2) On this basis,with styrene(St) and chloromethylstyrene(CMS) as monomers,their copolymerization was triggered by n-BuLi. It is found that the isotacticity of P(St-co-CMS) is about 45%.By FT IR,DSC,XRD and 13C-NMR,the product was demonstrated.3) DEAEMA was grafted to the P(St-co-CMS) by atom transfer radical polymerization, high isotactic amphiphilic and comb-like copolymer has obtained.And P(St-g-DMAEMA) was characterized by FT IR,DSC,TGA.4) The self-assembly of comb-like copolymer was investigated by DLS. The results showed that the size and PDI of the micelles were about 100nm and 0.146.The same time the morphologies,which was sphere,of the micelles was verified by TEM images.At pH1.4 or 7.4, controlled release behavior of SPM was studied and the results showed that The total release volume is 1.0302mg in p H 1.4 buffer solution,and pH 7.4 is 1.0989mg,release drug rate is 100% and uniform,it was demonstrated the micelle had good performance on drug Controlled release.