Synthese And Property Of Norfloxaxin-Metal Complexes

Norfloxacin is the third drugs of quinolones which have features of excellent activity, wide spectrum and low tociticy. Norfloxacin can bind with metal ions by the oxygen atom of the carboxyl group and carbonyl group. In this paper, some biological metal ions, such as Ni(â…¡), Co(â…¡), were selected to synthesize norfloxacin-metal complexes.1. A new Norfloxacin- Ni(â…¡) complexes were synthesized. Many techniques were used to analysis the structural properties such as infrared absorption spectroscopy, UV spectrometry, conductivity measurements, X-ray monocrystal analysis etc.2. A new Norfloxacin- Co(â…¡) complexes were synthesized. Many techniques were used to analysis the structural properties such as infrared absorption spectroscopy, UV spectrometry, conductivity measurements, X-ray monocrystal analysis etc.3. UV spectrometer was used to study the interactions of the two metal complexes with DNA. It was found that, as the DNA concentration increases, hypo chromic effect in UV spectrometer can be observed, but the red-shift in not obvious, which indicates that norfloxacin-metal complexes partly inserted into DNA. The binding constants of metal complexes with DNA were calculated and the interaction mode was discussed.4. UV spectrometer was used to study the interactions of the Nickel(II) complexes with fourteen substances of benzene kinds. It is found that, The complexes alternative enroll these substances of benzene kinds by counting their maximum hypo chromic effect.