The Optimization Of The Procedure For The Synthesis Of Ezetimibe

Ezetimibe as a new important medicine for lowering blood lipid, the sale has been increasing year by year since its first coming into the market from 2002. Compare with similar kinds of medicine in the market, ezetimibe is expensive due to the drawbacks such as its long synthetic steps, low yield and high cost. However, this medicine is still with good exploitation foreground and economic values. Based on the reported references, in order to shorten the synthetic route, increase the yield and lower the cost, our group have selected a convenient synthetic route and further optimized it, and led good result.