Study On Mannich Reactions Of Some Heterocyclic Amines

Mannich reaction is considered as amineomethylation. It is an important organic reaction in this century. In recent years, Mannich reaction has a new challenge with the green synthesis - that is to find environmentally friendly catalyst, free-solvent, ionic liquid and so on. In order to improve yield and reduce environmental pollution, we have designed three-component one-pot synthesis of 2 - aminothiazole derivatives, 2– amino - benzimidazole derivatives, 2– amino - 1, 3, 4 - thiadiazole derivatives under microwave irradiation,.Chapter One: Advance in Mannich Reactionthe Mannich reaction, Mannich reaction component, Mannich base and its applications, and Mannich reaction of development in recent years are reviewed. Chapter two: Study on Mannich Reaction of ¹H-benzo[d]imidazol-2-amine Three-component ,one-pot synthesis of 1 - ((¹H-benzo [d] imidazole -2 - amino) methyl) -2 - naphthol series of compounds by various aldehydes,β-naphthol, 2-amino-benzimidazol without any catalyst and solvents under microwave irradiation are described.This method has advantages of high yield, short reaction time and simple operation. The structures were confirmed by IR, 1¹H NMR and ¹³C NMR.Chapter three: Mannich Reaction of thiazol-2-amineSynthesis of 2-(phenyl (thiazol -2- ylamino) methyl ) naphthalen-1-ols by various aldehydes,β-naphthol, 2 - aminothiazole under the Microwave in the absence of any catalyst and solvent conditions are described. The structures of 2-(phenyl (thiazol -2- ylamino)methyl ) naphthalen-1-ols were confirmed by IR, ¹H NMR and ¹³C NMR.Chapter four: Mannich Reaction of 1,3,4-thiadiazol-2-amineWe have synthesized three different types of derivatives of 1,3,4-thiadiazol- 2-amine through one pot Mannich reaction of three components of aldehyde, compounds containingαactive hydrogen and 1,3,4-thiadiazol-2-amine or 1-(1,3,4-thiadiazol-2-yl)hydrazine by conventional methods. Their structures of the compounds have been confirmed by IR, ¹H NMR and ¹³C NMR.