| Due to their unique physical and chemical properties, heteropoly blue as the reduced state of Polyoxometalate have attracted more and more attention in recent years. So far, the study of heteropoly blue were mainly focused on the study of their physical and chemical properties and their application in catalysis, optics, and antiviral fields. As there are rich advantages of heteropoly blue, we introduced it into the application of biomedical science. Here we have synthesized heteropoly blue-based polymer nanoparticles and further investigated their application in cancer therapy and antiviral.We first synthesized a Keiggn [（CH3）4N]5[α-PMo2W10O40] according to the literature and studyed its photothermal property under 808 nm laser. Then ionic core-stabilized hydrophilic polymeric nanoparticles with enormous PEO chains were synthesized by chemically cross-linking using 1,4-dibromobutane as a cross-linker in DMF solution according to the previous report. By use of the charge interaction, [α-PMo2W10O40]5- was loaded in the core of polymeric nanoparticles to form HPB doped P4VP-b-PEO nanoparticles（HPB/P4VP-b-PEO NPs）. The particles were well dispersed with uniform morphology and the average hydrodynamic size was 280 nm, the photothermal conversion efficiency of HPB/P4VP-b-PEO NPs in water was 23%. The as prepared HPB/P4VP-b-PEO NPs was biocompatible with low toxicity and displayed nice cancer therapy effect under 808 nm laser.As the derivatives of Polyoxometalates, there were researches about the application of heteropoly blue in antiviral field. Here we synthesized HPB/CS nanoparticles in one step, the single particle size was 50 nm and its hydrodynamic size was 160 nm. The as-prepared HPB/CS NPs was water-soluble and displayed nice photothermal conversion ability. The antiviral effect showed HPB/CS NPs cooperating with 808 nm laser displayed better antiviral effect than pure HPB/CS NPs.
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