Preparation And Application Of Quaternary Ammonium Salt / Haloamine Modified Nanoparticles

In recent years, with the improvement of people’s living standard and the rapid development of economy, people begin to pursue higher-quality living environments.Therefore, for the improvement of human health and the living environment,research and development of novel, highly effective, non-toxic, durable antibacterial materials have become one of the main topics of the current researchers. N-halamine antibacterial materials attracted wide attention to researchers due to their wide antibacterial spectrum, long-term antimicrobial activity, non-toxicity, stability, and rechargeability. In this paper, two kinds of quaternary ammonium salt/N-halamine antibacterial nanomaterials were synthesized, and their antibacterial activities against gram-positive and gram-negative bacteria were studied. Also, the as–synthesized nanoparticles were used to prepare antibacterial water-based acrylic coating. The details are as follows:1. Quaternary ammonium salt/N-halamine/Si O2 hybrid antibacterial nanoparticles(Cl-AAC/DMH/Si O2 NPs) were prepared, and characterized by FESEM, FTIR, and BET. The effect of reaction conditions on morphologies of nanoparticles was studied. The excellent antibacterial activities of the as-synthesized Cl-DMH/Si O2 NPs against E. coli and S. aureus were proved via the minimum inhibition concentration(MIC) and minimum bactericidal concentration(MBC)method. The MIC values of the as-prepared Cl-AAC/DMH/Si O2 NPs are 16.00μg/m L for E. coli and 8.00 μg/m L for S. Aureus, respectively. Their MBC values are32.00μg/m L for E. coli and 16.00μg/m L for S. Aureus, respectively. The testing results show that the N-halamine functional groups of the as-synthesized Cl-AAC/DMH/Si O2 NPs have good stability and reproducibility.2. Quaternary ammonium salt/epoxy hydantoin-modified chitosan nanoparticles(Chitosan-GH NPs) were prepared via an ionic crosslinking method and were then transferred into quaternary ammonium salt/N-halamine-modified chitosan nanoparticles(Cl-Chitosan-GH NPs) by chlorination with Na Cl O. The as-synthesized Cl-Chitosan-GH NPs were characterized using a variety of testing methods. The effects of concentration and contact time of the as-synthesized Cl-Chitosan-GH NPs on the antimicrobial performance were studied. It was found that the as-synthesized Cl-Chitosan-GH NPs have very good antimicrobial efficaciesagainst E. coli and S.aureus. The MIC and MBC values are 25 and 30 μg/m L for E.coli and 15 and 20μg/m L for S. aureus, respectively.3. Waterborne acrylic paint was prepared successfully via an solution polymerization method and the ratio of acrylic acid, methyl acrylic acid, and butyl acrylate was optimized. Finally, quaternary ammonium salt/N-halamine antibacterial nanoparticles were added into the as-prepared waterborne acrylic paint to make it antimicrobial. It was found that the as-prepared acrylic antimicrobial coating still had0.23% of Cl+ after storage for 10 days under room temperature. Also, the process for waterborne acrylic antimicrobial paint is simple and easy to be scaled up.