| The environment problem caused by POPs(Persistent organic pollutants) has gotten extensive attention of the world. In this study used, we bulit a gel permeation chromatography column (GPC)-GC-MS method to detect OPFRs in the serum. This method is simple, rapid and accurate. The method could meet the requirements of the analysis of organic compounds in human serum analyze. It also compared the response of the OPFRs among PCI, NCI and El three kinds of ion source, and we finally selected the El ion source as ionization source due to stable and high response. We detected 7 kinds of organic phosphate flame retardants with mass spectrometry full scan analysis. Qualitative and quantitative ion of TPhP and TTP was optimized, and we chose the qualitative information of OPFRs which could more accurately reflect the structure. In the process of instrument analysis the OPFRS identification could be more accurate.The mean concentration of ∑7OPFRs, ∑8PBDEs, ∑2DPs, ∑5NBFRs and ∑12DL-PCBs were 442.6,119.0,3.8,17.0 and 4.5 ng/g lipid in pooled serum samples from Weifang city, respectively. The levels of each persistent organic flame retardants in pooled serum samples with various substances closely related to the use and production of the materials, and the concentration in the serum samples show great differences among different compounds. Based on the analysis of age and gender factors, five types of pollutants in the male and female serum samples shows no significant difference of distribution, and pollutant concentration presents a certain regularity in serum samples of different age. The concentration of PCBs which has been banned was higher in pooled serum samples of old ages, PBDE which has been gradually were higher in pooled serum samples of middle-aged, as for novel organic flame retardants (such as DPs, NBFRs, and OPFRs), the higher concentrations appeared in the youngest group.In this study, we collected the air gaseous phase samples, air particulate phase samples, diet sample and locals’indoor dust samples from Shandong Weifang Binhai Economic Development Zone to analyze the level of DL-PCBs, PBDEs, DPs and NBFRs. In this study, the level of PBDEs and NBFRs are dominated in brominated flame retardants, while PCBs and DPs concentrations are both at low level, and almost same with the background level. This is closely related to the place where the China’s most important brominated flame retardants production base is located. The base may have discharged or leaked emissions and pollutants during production and transportation process, leading to the influencing surrounding atmosphere, food and indoor dust. In this study, after the analysis of various media, we preliminarily estimated human exposure dose through inhalation, diet and ingestion of indoor dust. The main exposure pathway for DL-PCBs is dietary intake, which has a close relation with the production and use of DL-PCBs has been banned in our country. The exposure pathway of PBDEs is inhalation, because it has typical local source of emissions, resulting in higher levels of PBEDs in atmosphere. DPs and NBFRs exposure is relatively low, less risk to human health.
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