Design Of Quasi-physiological Pulsatile Flow Simulation And Control

Seek an appropriate method of constructing vascular tissue engineering is the field of vascular tissue engineering research scholars. States reported the focus Vascular as an ideal alternative, it should have good mechanical tension, strong enough to withstand the arterial blood flow impact without rupture; Vascular with biological activity, temperature, blood flow changes corresponding contractile response and secreting corresponding bioactive substances. One of the most important is the alternative vascular mechanical properties to withstand prolonged blood test, this is the vascular defect repair the key to success. Hydrodynamics of the blood vessel wall of a long-term study, the scholars design can simulate the bodyblood circulation, vascular pulsatile devices ----- vascular bioreactor, andsuccessfully used in construction of tissue-engineered blood vessels. Related research on the reactor although different characteristics, but their common characteristic is the simulation of the human vascular and pulsatile flow erosion, in mechanical revascularization main factors hemodynamic effects, in particular the impact of pulsatile flow. However, quasi-physiological state of the pulsatile flow relatively little research.In this paper, the fluid dynamics of blood on the basis of Construction quasi-physiological arterial pulsation mixing parameter model and analog circuit network using MATLAB software simulation model circuit, the simulation of the data from quasi-physiological artery pulsatile flow device for theoretical guidance. The main thesis as follows:(1). Right at home and abroad in vascular tissue engineering research in the field of literature the analysis concluded. Vascular reconstruction process hemodynamic principle outlined, Particularly quasi-physiological pulsatile flow in vascular reconstruction to the role in the detail.(2). According to the principle of cardiovascular hemodynamics, in the arteries of the distribution parameters and lumped parameter model based on six types of analog circuit network to simulate the quasi-physiological State of arterial pulsation flow. These six types of analog circuit is the unique point system parameters of change and the importation of constant current is unchanged. Using MATLAB software on six circuit network model of computation and simulation, simulated data and the results of a detailed analysis.(3). Physiological analysis of quasi-physiological arterial pulsatile flow device with the principles developed on the basis of the characteristics, production system, and to design and construct quasi-physiological artery pulsatile flow device. The experimental setup of the various components of a detailed briefing, Special installation of control equipment-liquid and liquid containers with resistance, which is the key device control components, Real-time high requirements, the production of more complex. Quasi-physiological arterial pulsation flow measurement and control system is a typical data acquisition system from sensor, small-signal amplifier, data acquisition cards, multi-serial expansion cards, peristaltic pump, linear motors, computer and other components. Through multi-function data acquisition card to achieve quasi-physiological pulsatile flow pressure device, the flow of information detection. And the use of small-signal amplifier small sensor output signal conditioning, in order to facilitate data collection and computer control..(4). C + + Builder 5.0 application development tool to complete quasi-physiological artery pulsatile flow device monitoring and control of software development , the Real-time data acquisition and processing using multithreading technology. Serial Programming peristaltic pump control and linear stepper motor control, design and construct a distributed linear stepper motor control systems and control protocol. Under pressure sensors and flow sensors, developed a sensor calibration procedures, Experiments are right to collect pressure and flow signal calibration to provide a great convenience.(5). Discussed the simulation and device production process with the focus on difficult, and the next step in improving the device further forecast.