Study On Intraruminal Controlled Release Preparation Of Containing Ivermectin Prescription

Controlled released preparation has been popularly applied in ruminant for anti-parasite because it can remain and release drugs in intra-ruminant for a long time. This article summarized the characterizations, origination, research development and practical application at home and abroad, about controlled released preparation and sustained release preparation of Ivermectin and Albendozale. Three groups intraruminal controlled release preparations of containing Ivermectin and Albendozale prescription were made in laboratory with polymer PVC. Ultral-violet spectrophotometry was used for determining the quantity of released drugs of intraruminal controlled release preparation of containing4Ivermectin and Albendozale. The equation of Ivermectin and Albendozale has good lineal relation. Ivermectin is A=0.0496+0.0517C (r=0.9999), and Albendozale is A=0.0054+0.0555C (r=0.9996). The results showed that the Ivermectin and Albendozale released quantity of the number of 1-5 of group I preparation were 10.0332 ± 0. 736mg. d, 33.724±1.890mg. d, the number 6~10 of group I preparation were 10.676± 0. 705mg. d, 33.473 ±1.928mg. d, the group 11 preparation were 5.013 ± 0. 208mg. d, 22. 080± 1. 216mg. d, 5. 193 ± 0. 431mg. d, 21. 887± 1. 1 14mg. d, the group 111 preparation were 4.058 ± 0.419rng. d, 18. 519 ± 0. 498mg. d, 41.521±0. 504mg. d, 19. 313±0. 609mg. d. After this, the stability of the three group preparations were determined, the results showed that it was not obviously significant between the preparations in room temperature and in 37. 5 ℃. And then high performance liquid chromatography (HPLC) method was used to delect the blood plasma concentration of Ivermectin and Albendozale with Dual λ Absorbance Detector at the same time, which have the good lineal relation in the range of 40-640ng/ml, the equation of Ivermectin is y=0.0077+0.0117C (r=0.9994), Albendozale is Y=0.0578+0.0027C (r=0.9680). With the same method the recovery of Ivermectin and Albendozale in blood plasma concentration 60. 240. 480ng/ml were 93.5%. 98.3%, 98.7% and 94.2%, 97.6%, 101.4%. The group II preparation has reached the ideal objectiveplanned before the experiment through comparing the concentration, stability and the quantity of drug released every day among the three group preparations.