| sOrientobilhaiziasis was one of the schistosomiasis, Oriertiobilharzia spp. parasitize in portal and mesenteric veins of cattle, sheep and other animals. It mostly distributed in Asia and Europe, and distributed in 23 provinces (regions) of China. The epidemic of Orientobilharziasis was reported by India, Iran, Jilin, Sichuan and Shanxi province of China. Because of the difference of geography it had different epidemic situation, the epidemic of the Orientobilharziasis of cattle and sheep in Heilongjiang province was investigated. According to traditional taxonomy that Heilongjiang had three species of Orientobilharzia: O.turkestanica, O.turkestanica vai.tuberculata and O.cheni. Their intermediate hosts were R auricularia, R. ovata and Gpervia. Orientobilharziasis was one of the main parasites of cattle and sheep which widely distributed in 27 county (city) of 34 county (city) of Heilongjiang province, the average infection rate of cattle and sheep was 43.97%(714/1624) and 61.98%( 1503/2425), respectively. Qiqihar was the most serious regions, it had a level of 62.7%(345/550) and 76.93%(1017/1322) in cattle and sheep respectively. Daqing, Suihua, Harbin and Beian districts' infection rates were also higher; it was also scattered in Jiamusi, Heihe, Jixi, but it had not been found in Mudanjiang then, the integumental surface of O.cheni and O. turkestanica var.tuberculata by the scanning electron microscope was also observed after they were identified by light microscope in the bodies of cattle and sheep. Meanwhile the results of the integumental surface was compared with mat of O.turkestanica by Tang Chongti under electron microscope and analyzed them. By means of observing, comparing and analyzing, It showed that both of O. cheni and O. titrkestanica var.tuberculata were the same species, they might only be of different name with O. turkestanica or subspecies or geographical strain, primarily.The key of Synthetic Prevention techniques for Orientobilharziasis was early diagnosis and the development of high efficacy medicine. The research adopted the advanced immune diagnostic in the world-Dot Immune Gold Filter Assay (DaIGFA), which had been applied to diagnosing the early Orientobilharziasis. The result showed that it had many advantages, suchas easy manipulation, high sensitivity, intensive specificity and early determination and so on. Compared with autopsy, the positive rate was 98.53%(67/68) and the negative rate is 97.78%(44/45). The cross reaction with Fasciola hepatica was 2.86%(l/35). It had no cross reaction with Eurytrema pancreaticurn and Paramphistomurn cervi. DIGFA could examine antibody on the seventh day like ELISA after artificial infection. Compared with precipitating method and incubating method. DIGFA had a significant difference (p<0.01), but had no significant difference (p>0.05) with ELISA by x2 test. In the aspect of curing medicine of Orientobilharziasis 7.5% compound praziquentel injection was developed with the main raw material-praziquentel. The injection was given to sheep at a dose of 15mg/kg; the rate of Orientobilharzia 's eggs turning into the negative and the reducing rate are 85% and 95.69% respectively. The result was similar to taking orally medicine at a dose of 40mg/kg. It saved 62.5% medicine. Meanwhile, this drug also had a good effect on gasteointestinal nematodes and Moniezia to sheep, so it was a high efficacy, broad-spectrum and low toxic anthelmintic medicine.This study accomplished in many aspects in detail: including epidemic, the taxonomic status, diagnostic method and curing medicine of Orientobilharziasis in Heilongjiang. It had almost been known the species, infection rate, infection intensity, distribution in geography and its species of intermediate hosts' regulation of decrease and increase, and the relation of 3 species of Orientobilharzia. They had also established a good diagnostic method and developed an effective drug. It had an important significance to control the Orientobilharziasis in Heilongjiang..
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