Monitoring And Comparison Of Immune Antibody Titres Of Three Different Mycoplasma Hyopneumoniae Vaccines

Porcine Mycoplasmal pneumonia is caused by Mycoplasma hyopneumoniae, which is a high infectious, chronic, high morbidity and low mortality respiratory disease in swine herds, and is one of important diseases caused great economic losses in the pig industry worldwide.The main measures to prevent and control the disease is choice of operative fine quality vaccines to immune herds of swine and strict sanitation. There have been two bacterial vaccines, death vaccine and avirulent live vaccine, to prevent mycoplasma hyopneumoniae of swine. Live vaccines have high immunogenicity and can induce cell immunity, but it is injected into pigs by thoracic cavity injection. Live vaccine needs practiced veterinarians and need prohibit to use antibiotics within 15 days after vaccinization. Killed vaccine mainly induces body fluid immunity and has good reliability. Moreover, killed vaccine could induce cell immunity, body fluid immunity and mucus immunity by adding specific immune increasing effect adjuvant in order. Thereby, killed vaccine has higher immunogenicity. Killed vaccine is simply immunized into pigs by muscle injection and its immunity is not interfered by antibiotics in feed. There are many killed vaccines in the market. We chose a reliable killed vaccine from RESPISURE vaccine , M+Pac vaccine and native killed vaccine by detecting immune antibody level with ELISA to immunize swine herds in order to prevent and control mycoplasma hyopneumoniae of swine. The results showed that antibodies of nurse pigs first immunized in 7th day were positive from twenty-first day to forty-second day, but the antibody levels of them had discrepancy. Average antibody titre of A group, B group, C group and control group respectively was 0.971,1.365, 0.784 andO.099 at 21 days after first vaccinization. Average antibody titre of A group, B group, C group and control group respectively was 0.952, 1.229, 0.710 and0.048 at 21 days after second vaccinization. The results manifested B vaccine had good immunogenicity and high antibody level, followed A vaccine, and C vaccine was worse in three vaccines.