Effects Of Different Dosage Forms Of Fluvastatin On Insulin Resistance And Hypersensitive C - Reactive Protein In Mice With Metabolic Syndrome

Objective:The pathophysiology of metabolic syndromes is insulin resistance and hs-CRP as an inflammatory factor get involved in it. As we know, statins widespread used in metabolic patients, but new researches found that as large doses of statins intake, drug concentration in circulation had increased dramatically and led to increase adverse reactions. My research evaluated the effects of fluvastatin on insulin resistance and hs-CRP level in metabolic syndromes rats’model, so that support more evidences in the best therapeutic dosage.Method:60male KM rats were randomly divided into two groups:10rats in control (normal diet) and50rats in model (high lipid diet). By the end of the4th week,10rats selected randomly in model group were killed so that the metabolic syndromes models were established. From the5th week, the remainder40rats were randomly divided into A、 B、 C and D four groups, then were administered intragastrically with fluvastatin capsule of6mg/kg/d, fluvastatin capsule of12mg/kg/d, fluvastatin slow-release tablet12mg/kg/d and saline at a same dosage respectively, and all the rats were fed on normal diet for4weeks. All the rats were killed by the end of the8th week. The levels of TC, TG, LDL-C, HDL-C, FBG, FINS, hs-CRP were measured respectively and then calculated homeostasis model assessment of insulin resistance.Results:1. By the end of the4th week, compared with control, the levels of TG, FBG and FINS were increased while HDL-C was decreased significantly (P<0.05) in model, and then calculated homeostasis model assessment of insulin resistance, the metabolic syndromes models were established.2. At the end of the experiment, compared with group D, the levels of TC, TG and LDL-C were decreased significantly (P<0.01) while HDL-C were increased significantly in A, B and C groups (P<0.05). Compared with group A, the levels of TC, TG and LDL-C were decreased (P<0.05) while HDL-C were increased significantly in group B(P<0.05). Compared with group B, the levels of TC, TG and LDL-C were decreased (P<0.05) while HDL-C were increased significantly in group C (P<0.05)3. At the end of the experiment, compared with group D, the levels of hs-CRP, FBG, FINS were decreased significantly (P<0.05) in A, B and C groups. Compared with group A, the levels of hs-CRP, FBG and FINS had no change in group B (P>0.05) Compared with group B, hs-CRP, FBG, FINS and HOMA-IR were decreased significantly in group C (P<0.05)Conclusion:Fluvastatin could reduce TC, TG, LDL-C, FINS, hs-CRP level and improve insulin resistance, the effects is more apparent in a large-dosage and slow-release tablet especially, and that may attribute to its anti-inflammation effects.