Simulation Of DNA Double - Strand Breaks Caused By Radiation Therapy Of Proton Beam Tumors

Proton beams radiation is an high LET radiation in radiotherapy.Using the Proton beams for radiotherapy, the Bragg peak can accuratelyalign the area of the tumor and minimize the damage to healthy tissue.The research of radiation biological effects for proton beams is animportant field of radiation biology and radiation therapeutics. DNA isthe main target molecule of proton radiation. It is an extremely complexprocess for proton beams acts on biological tissue and lead to variousbiological effects, especially the double-strand break (DSB) is the mostbasic and important original injury for proton radiation. For the biologicaleffects of proton beams radiation will be directly involved in the processof proton radiotherapy and effect the success of radiotherapy. This paperutilizes the latest Monte Carlo simulation (MCDS) software for thesimulation of proton beams radiation in typical of human cells. Wesimulate the proton beams radiation with different energies. Bysimulating, the DSB yields were obtained with different energies. Bycompared the SSB and DSB yields to60Co radiation we obtain the RBEfor SSB and DSB induction. At the same time, we explored the effects ofoxygen concentration in DSB induction. It provide comparative data forexperimental study of proton beams therapy and it is significance for theprotons beam used in clinical cancer therapy.