Study On The Pharmacodynamics And Curative Effect Evaluation Of Professor Zhu Jiangui Treating Insomnia Based On Data Mining

Objective:To summed up treatment based on syndrome differentiation of Professor Zhu Jiangui in the treatment of insomnia through curative effect evaluation of complex network research and data mining.and provide experiences and methods.for treatment of insomnia in TCMMethods:The papered cases of director Zhu Jiangui clinic diagnosis and treatment of patients with insomnia were collected, classified according to the criteria, puting into the computer,which includes the basic information of patients, four diagnostic information, traditional Chinese herbs prescription, the Pittsburgh sleep scale before and after the treatment. The traditional Chinese herbs syndrome and prescription and names of are standardized. Exact the excel tabledocuments from the database,using the complex network diagramto associate and produce complex network diagram and find out the regularity. Put the effective prescription into the analysis of complex networks. Method for generating the complex network graph is, in the homogeneous network, according to the patient’s Hospital ID, create a hierarchical net project analysis of project, algorithms,select settings network diagram, Layer num 3, degree coefficient isl.3, to generate the network graph as the standard. Collect the scores of Pittsburgh statistics before and after treatment, and analyse the statistics of effective cases by complex network, finally conclude the law of the syndrome differentiation in the treatment of insomnia by professor Zhu.Results:the use of herbs on most types are warm type, common herbs and cold herbs are second. In the frequency use of common herbs was the most, followed by the cold herbs. Sweet pungent are mostly in the type and frequency of use. The use of herbs of the liver meridian throughare the most, followed by the lung and spleen stomach kidney and heart. Bitter sweet Ping are closely correlated, followed by Xian cold Xin. The location of heart and liver, followed by kidney and lung. Main treatment for calming the liver and clearing heat, promoting blood circulation,, with qianYang Zhen Jing, with the convergence of water, eliminating phlegm, strengthen the Qi and eyesight, purging fire, removing phlegm and dampness (degree 38), nourishing yin nourishing liver (degree 22), drive away constipation (degree 16), to remove qi stagnation (degree 0). In the sub network, the treatment of high frequency and relevance is, Xiaoji and smooth the qi motion, remove the phlegm and dampness, soothing the liver and gallbladder, Xingshen and remove phlegm, and strengthen Yin harmony Ying, strengthen yang, leading yang to its position, clearing the meridian, warming the cold meridian, remove blood stasisxlear the heat in lung, nourishing the lung yi, antiperspirant, astringent, regulating Ying and Wei.In network 3, soothing the liver to stop the wind, remove dampness, nourishing essence,leading yang to its position, leading the blood down, strengthen the bones and muscles, activate collaterals, nourishing liver and kidney, dispelling the cold and warm, soothing stomach, nourishing lung and astringent fine, widen the chest and remove phlegm; strengthen digestion, elimination of water and gas,discharge heat; swelling,remove pus, diffusing the lung and relieving sore throat, dispelling wind and heat. high frequency herbs used by Professor Zhu, areliquorice, Poria, concha mauritiae teeth, amber, semen Ziziphi Spinosae, Coptis chinensis, Rhizoma Anemarrhenae, Pearl powder.Conclusion:the treatment of professor Zhu are in different syndrome, are not a single sydnrome, multiple syndromes exist together, the main syndrome is liver heat and blood stasis, Hung Up. Main treatment is calming the liver and clearing heat, promoting blood circulation,, and leading Yang to its position and Zhen Jing, with the convergence of water, eliminating phlegm, strengthn Qiand eyesight, remove fire phlegm and dampness. The.core herbs used by Professor Zhu used are, liquorice, Poria, concha mauritiae teeth, amber, semen Ziziphi Spinosae, Coptis chinensis, Rhizoma Anemarrhenae, Pearl powder. Take Anshen Dingzhi Wan (dragon, Poria cocos. Poria, Radix Polygalae, Shi Changpu, Codonopsis pilosula, cinnabar, Mei Wan of amber(amber, antelope horn, Codonopsis, Poria, Polygala, licorice), combined withsemen Ziziphi Spinosae decoction. Through the treatment of insomnia syndrome to infer the, liver yin deficiency of heart and spleen, deficiency of Qi and blood, Qi deficiency and phlegm heat, deficiency heat syndrome under chilling kidney disharmony, Ying and Wei Yang deficiency disorders and qi stagnation of liver qi, heart Huo Wang, or fire or liver stagnation and spleen deficiency, phlegm dampness phlegm heat, blood stasis.are the main sydromes.