Clinical Study On Treatment Of Subacute And Chronic Eczema By Compound Sophora Flavescens

Objective:The experimental study on KuShen Antipruritic compound ointment in the treatment of subacute and chronic eczema carry on the comprehensive evaluation, clear its clinical curative effect using method and safety. Aim to provide patients with subacute and chronic eczema a obvious effects of itching, skin and not contaminated clothing, less adverse reaction and can be long-term used of drugs for external use only.Methods:All of the patients of the clinical trials research were diagnosed with eczema, according to the skin is divided into two types, subacute and chronic eczema, each model is divided into the treatment group-KuShen Antipruritic compound ointment and control group-the placebo group with cream paste matrix.2 weeks for a period of treatment, patients with subacute eczema treat 1 treatment course, a group of patients with chronic eczema treat 2 courses of treatment. After each course Conclusion the curative effect. Using randomized, double-blind, placebo-controlled clinical trial method, carry on the comprehensive evaluation of the skin lesion subsided, itch relief, drug safety and so on. Before the cure, with a detailed record the general clinical data of each patient,at the same time, analyzing the characteristics of the onset of eczema and induce contributing factors.Results:The experimental received 160 patients,20 cases were unfinished the loss rate was 12.5%.15 cases did not return on time,5 cases for added with other internal or external drugs. Treatment group (KuShen Antipruritic compound ointmen) markedly effective rate was 55.71%, the control group (the placebo group with cream paste matrix) markedly effective rate was 21.43%; Treatment group total effective rate was 88.57%, control group total effective rate was 48.57%. Total effective rate between the two groups compare with the statistical inspection, p=< 0.05, there was a significant difference, the curative effect of treatment group is better than the control group; Markedly effective rate between the two groups compare with the statistical inspection, p< 0.05, there was a significant difference, the treatment group,s curative effect is better than the control group. The subacute eczema group, the treatment group markedly effective rate was 57.14%, the control group markedly effective rate was 21.88%; Treatment group total effective rate was 92.86%, control group total effective rate was 50%. Subacute eczema total effective rate between the two groups compare with the statistical inspection, p< 0.05, there was a significant difference, the treatment group better than the control group in the curative effect; Markedly effective rate between the two groups compare with the statistical inspection, p< 0.05, there were significant differences, the treatment group better than the control group in the curative effect. For the Chronic eczema group, the treatment group markedly effective rate was 53.57%, the control group markedly effective rate was 21.05%; Treatment group total effective rate was 82.14%, control group total effective rate was 47.37%. Chronic eczema, total effective rate between the two groups compared with the statistical inspection, p< 0.05, there was a significant difference, the treatment group better than the control group in the curative effect; Markedly effective rate between the two groups compare with the statistical inspection, p<0.05, there was a significant difference, the treatment group better than the control group in the curative effect. In alleviating pruritus, reducing lesion area and improving the skin form, KuShen Antipruritic compound ointmen is obviously better than the placebo group (p< 0.05). After did not see the blood, urine, kidney function, electrocardiogram (ECG) abnormal cases, not seen safety events in connection with this drug.Conclusion:KuShen Antipruritic compound ointment for the topical treatment of subacute and chronic eczema has a determined curative effect, it is safe and reliable.