| Hepatitis b cirrhosis is caused by hepatitis b virus long-term damage the liver and chronic, progressive liver disease. According to the illness weight, can be divided into the compensation period and decompensation period, including compensatory period patients usually have no obvious symptoms or signs, physical examination can have mild swelling of the liver, hard texture, and also can appear mild splenomegaly, liver palm or spider nevi, decompensation period patients with portal hypertension and liver function damage as the main performance, and how the system involved, concurrent with upper gastrointestinal bleeding, hepatic encephalopathy, secondary infection, the splenic function, ascites, cancer and other disease.Traditional Chinese medicine thinks, the hepatitis b cirrhosis of the liver is belong to the traditional Chinese medicine "accumulation" and "ballooning" disease category, the basic pathogenesis of vital qi, damp heat evil poison keep in liver meridian, qi activity stasis, vein blood stasis resistance, long. According to the early stage of the research study, diseases with ease, blood stasis blocking collaterals, damp and hot liver, liver and kidney Yin deficiency, spleen kidney Yang deficiency is a common basic pathogenesis of the disease, such as compensatory period mainly qi deficiency, qi depression, Yin (blood) deficiency, blood stasis and damp heat syndromes.The liver blood and pathogenic factor not only complement each other in physiology, for with each other, but also influence each other pathologically. If the pathogenesis of liver function impairment, diseases with stasis, further can lead to blood stasis; Gas YuHua fire that forced blood, or diseases with inverse, along with the reversed flow of qi, blood can cause bleeding; If insufficient Yin blood, lost its cool to be soft, can lead to liver Yang ascending function too, or even lead to hand pneumatic; Liver anaemia empty, lost its can moisten, can lead to muscle alongwith etc. The pathology characteristic that liver summarized as two words:liver cathode is deficient and KangCheng to body, liver with anode Yi Kangcheng to be deficient.Based on the basic pathogenesis characteristics of hepatitis b cirrhosis of the liver and liver as theory of TCM, the research thought of liver for just the dirty, Yin with Yang, hidden for the body with blood, and blood to support for use, both closely related, in the treatment of liver cirrhosis early phase (compensation), should pay attention to both Yin nourishing blood of liver. Group combining traditional Chinese and western medicine in clinical intervention strategy, put forward the design by the following observations according to the intervention of hepatitis b cirrhosis of the liver as theory of TCM, randomized, double-blind controlled study. In western medicine use nucleoside antiviral drugs on the basis of the proposed treatment group 1 (in "replenishing qi, spleen, liver and qi, soft firm t2dm" for the principle of formula), the treatment group 2 (in "replenishing qi, spleen, liver and qi, soft firm t2dm, ziyin yangxue (liver)" for the principle of formula), and establish a placebo (simulation, simulation treatment group (2) as the pathological control group.Tongue instrument is through the camera lens on the patient’s tongue, and then further analyze the tongue color, moss color parameter information such as the automation instruments, in recent years has been widely applied in clinical practice and evaluation of curative effect. Among them, the tongue color parameters for its can be implemented in the quantification of tongue diagnosis, standardization and objectification plays an advantage in clinical diagnosis and treatment of this topic with the tongue color parameters as observation indexes, will be collected and analyzed the tongue color parameters of the cases of patients with hepatitis b cirrhosis compensatory period data were analyzed, and the observation of hepatitis b patients with liver cirrhosis compensatory period of gender, age, and between groups, such as the change of the tongue color parameters before and after the intervention to understand the epidemiological trends, analysis of hepatitis b patients with liver cirrhosis compensatory period between groups before and after the intervention of tongue color parameters change characteristics, from the aspects of tongue color parameter analysis of drug treatment effect, to explore objective of traditional Chinese medicine tongue color parameters for hepatitis b patients with liver cirrhosis compensatory period efficacy judgment of value.Objective:1 from the aspects of objective tongue color parameter to "replenishing qi, spleen, liver and qi, soft firm t2dm" therapeutic principles combined with "ziyin yangxue (liver)" drugs for the treatment of patients with hepatitis b cirrhosis compensatory period clinical curative effect.2 discuss based on the objective tongue color of traditional Chinese medicine tongue diagnosis instrument parameters for hepatitis b patients with liver cirrhosis compensatory period efficacy judgment of value.Methods:1 Using clinical multicenter, randomized, double-blind, simulation comparison of epidemiological investigation research method, using TCM intervention the clinical effect of the treatment of hepatitis b cirrhosis (compensatory) table (CRF) and tongue like instrument, in January 2014-December 2014 in the 302th hospital of the Chinese people’s liberation army, Beijing ditan hospital, affiliated to the capital university of medical sciences, China academy of traditional Chinese medicine xiyuan hospital met inclusion and exclusion criteria, outpatient and hospitalization of patients with hepatitis b cirrhosis compensatory period general condition information, symptoms, signs, including the content of the tongue body color such as tongue) and so on carries on the collection, and finally into the measurement and analysis of 0,3 months,6 months of 84 cases of patients with tongue color parameters.284 cases of TCM syndrome differentiation of qi deficiency, qi depression and blood stasis patients with hepatitis b cirrhosis compensatory period were randomly divided into treatment group (30 cases) 1,2 (28 cases) and treatment group, the placebo group (26 cases). Three groups of all routine treatment. Among them, the treatment group 1 on the basis of routine therapy, with "replenishing qi, spleen, liver and qi, soft firm t2dm" as a principle of formula for traditional Chinese medicine therapy (prescription:raw huangqi 15 g,15 g, Fried atractylodes main licorice 10 g, vinegar radix bupleuri 10 g, fry hovenia dulcis 10 g,15 g vinegar turtle shell, peach kernel,10 g, salvia miltiorrhiza 15 g), the treatment group 2 on the basis of routine therapy and the treatment group 1 with "ziyin yangxue (liver)" drugs (prescription:raw huangqi 15 g,15 g, Fried atractylodes main licorice 10 g, vinegar radix bupleuri 10 g, fry hovenia dulcis 10 g,15 g vinegar turtle shell, peach kernel,10 g,15 g, salvia miltiorrhiza fry 15 g, root of herbaceous peony root, 10 g medlar 10 g, angelica root,10 g), and the placebo group on the basis of routine therapy for analog simulation treatment group (2) agent treatment, groups of Chinese medicine granules are 2 bags per day,200 ml each time,2 times of oral sooner or later. Three group of patients treatment for 6 months. All three groups of patients during treatment adopt nucleoside antiviral drugs as the foundation treatment. Collection and analysis before the intervention (0), (3 months) in the intervention, intervention (6 months) of three groups of patients after tongue color parameters, compare groups of patients before, during and after the intervention on both sides of the tip of the tongue and the tongue tongue color R, G, B value and R2/(R+G+B), G2/(R+G+B), B2/(R +G+B) (article ’R’, G, B’to respectively), H, S, V value.3 The use of Shanghai university of traditional Chinese medicine and Shanghai for both computer software research and development,LTD tongue like collection and analysis software for collection and determination of the tongue figure on the left side of the tip of the tongue, tongue, tongue color on the right side of the tongue of the R, G, B, H, S, V value (RGB value can reflect the tongue color and brightness, HSV value can reflect the tongue color, light and shade, etc.). RGB color model, the R, G, B single score changes, is not true in the change of the red, green, and blue, because of need and according to the change of the other two values, can more accurately evaluate its changes. Therefore, in this study, the R, G, B further revised to R’, G, B, calculation formula is:R’=R2/(R+ G+B), G’=G2/(R+G+B), B=’B2/(R+G+B).4 The data entry physi CAL unified management platform is adopted to establish the database, by two independent input data and for a second check. Using SPSS 20.0 statistical software, measuring data lines of normality and homogeneity of variance test, meet the requirements using single factor analysis of variance, does not meet the requirements the Kruskal-Whitney rank and inspection comparison differences between groups, and carry on the comparison of two, count data by chi-square test comparing the difference between the groups. Statistical inference in 0.05 as the inspection level.Result:1 General information:in the group’s collection of 144 cases of hepatitis b patients with cirrhosis, the selection of the measured 0,3 months,6 months on both sides of the tip of the tongue and the tongue, a total of 84 patients with tongue color parameters were analyzed, and the male 58 cases (69.0%), the average age was (47.34±8.27), the female 26 cases (31.0%), the average age was (50.85±8.92); The treatment group (30 cases),1 the male 18 cases,12 cases, the average age was (50.17±7.70); The treatment group (28 cases),2(17 male and female in 11 cases, the average age was (48.93±10.12); The placebo group (26 cases),23 cases of male and female 3 cases, the average age was (45.88±6.98).2 The tongue color parameters:1) the placebo group after treatment tongue color parameters:in the first three months of R, G, B value, R, G, B’,’V values are on the rise, after three months increased slightly or unchanged. Among them,6 months after treatment, compared with 0 months, placebo in patients with the tip of the tongue of tongue color value B, B’were significantly increased (P<0.05);2) after the treatment group 1 tongue color parameters:the first three months of R, G, B value, R, G, B’,’V values were rising trend obviously, after three months appeared a downward trend. Among them,3 months after treatment, compared with 0 months, the treatment group 1 patients with the tip of the tongue of tongue color G value, B, G ’and’ B were significantly increased (P<0.05); Six months after treatment, compared with 3 months, the treatment group 1 patients with the tip of the tongue of tongue color G value, B, G ’and’ B were significantly lower (P<0.05); On the left side of the tongue tongue color values of R, R’, V value were significantly lower (P<0.05).3) after the treatment group 2 tongue color parameters:six months after the treatment of R, G, B value, R, G, B’,’V values were rising trend obviously, three months ago. Among them,3 months after treatment, compared with 0 months, the treatment group 2 patients with the tip of the tongue of tongue color R value, G, B value, G, B’,’V values were significantly increased (P<0.05); On the left side of the tongue tongue color values of G, G’were significantly increased (P<0.05); Tongue the right value of tongue color G, B value, G, B’,’V values were significantly increased (P<0.05). Six months after treatment, compared with 0 months, the treatment group 2 patients with the tip of the tongue of tongue color value R, G, B value, R, G, B’,’V values were significantly increased (P<0.05); On the left side of the tongue tongue color values of G, G’were significantly increased (P<0.05); Tongue the right value of tongue color G, B value, R’, G, V value were significantly increased (P<0.05).4) tongue color parameters between groups after treatment comparison:0 months,3 months, the placebo group, the treatment group, treatment group 12 tongue color parameters is no statistical difference between groups (P>0.05).6 months, the tip of the tongue of tongue color R, G, B value,’R’, G, B’,2 V value of treatment group were significantly higher than treatment group 1(P<0.05); R and B values, R’, V the placebo group were significantly higher than treatment group 1 (P<0.05). On the left side of the tongue tongue color R, G, B value, R’, G’,2 V value of treatment group were significantly higher than treatment group 1(P<0.05); R, R’, V values the placebo group were significantly higher than treatment group 1 (P<0.05). Tongue color values of R, R ’on the right side of the tongue,2 V value of treatment group were significantly higher than treatment group 1 (P<0.05).Conclusion:1 The "yiqi spleen, liver and qi, soft firm t2dm" drugs in principle are the "ziyin yangxue (liver)" drugs, tongue color brightness in patients with hepatitis b cirrhosis compensatory period and the improvement of the degree of dark purple is superior to the simple use of "yiqi spleen, liver and qi, soft firm t2dm" treatment and a placebo. But from the perspective of tongue color reflect its treatment the curative effect of hepatitis b cirrhosis compensatory period.2 Based on the tongue instrument and the objectification of tongue color parameters, can reflect the hepatitis b patients with liver cirrhosis compensatory period before and after the intervention of tongue color changes in the micro level, therefore, to a certain extent, reflects the effect of drug intervention, for further research in the future the tongue color parameters and provide certain basis for the correlation of drug efficacy.
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